Neuwirth made her Broadway debut in the role of Sheila in A Chorus Line in 1980. She has been featured in revivals of Little Me (1982) Sweet Charity (1986), for which she received a Tony Award for Best Featured Actress in a Musical, and Damn Yankees (1994). It was with the 1996 revival of Chicago, in which she starred as showgirl and killer Velma Kelly, that she gained her greatest stage recognition. Her performance garnered her Tony and Drama Desk Awards as Best Lead Actress in a Musical. She voiced Binky in the series of CyberChase. In 2004 she mounted a show, Here Lies Jenny, that featured songs by Kurt Weill, sung and danced by Neuwirth and a four-person supporting cast, as part of an unspoken ambiguous story in an anonymous seedy bar possibly in Berlin in the 1930s. This show was performed in the Zipper Theater on W. 37 St. in New York, initially only at 11 p.m. on weekends. It was eventually expanded to include an earlier show. Here Lies Jenny was also presented by Ms. Neuwirt