Valderrama recently appeared in the Los Angeles Times critic's choice play Blackout, an adaptation of the feature film Drunks, and starred opposite Anjelica Huston and Ben Kingsley in the Actors' Fund of America one-performance only reading of Sunset Boulevard. He has completed filming the short film La Torcedura in which he plays the lead, and recently wrapped production on The Darwin Awards, an independent film directed by Finn Taylor, starring Winona Ryder and Joseph Fiennes.

In animation work, Valderrama voiced Rodrigo in Clifford's Really Big Movie, playing alongside John Ritter, Wayne Brady and Jenna Elfman. He also voices the main character, Manny, in Disney Channel’s Handy Manny series for preschoolers. He had starring role in El Muerto, an indie film directed by Brian Cox and based on the successful comic book created by Javier Hernandez. In January 2007, Valderrama announced that he would launch his own men's fashion label called "Calavena".

Valderrama made a