Virginia Mayo (November 30, 1920 – January 17, 2005) was an American film actress.

In 1947, she married actor Michael O'Shea, who died in 1973. They had one child, Mary Catherine O'Shea (born in 1953). The O'Shea family lived for several decades in Thousand Oaks, California.

In the 1990s, Mayo donated her extensive collection of Hollywood memorabilia to the Thousand Oaks Library. She died of natural causes in Los Angeles in 2005 at the age of 84.