Myles was born in London, the daughter of Jane, who works in educational publishing, and Peter Myles, an Anglican vicar in Isleworth, West London. Her maternal grandmother was Russian. She grew up in Notting Hill, where her father worked at the church of St. George the Martyr, and attended Fox Primary School. At the age of eleven, Myles moved with her family to Isleworth. Following success at her Read more...

Since 1996, Myles has appeared in a number of both American and English films and television productions. In 2001, she got a small role as Johnny Depp 's wife, Victoria Abberline, in the thriller film From Hell. She had a supporting role in the 2003 film Underworld and in sequel Underworld: Evolution (in a brief flashback scene). In 2004, she played the schoolgirl lead in the thriller Out of Bounds Read more...

Myles was in a relationship with actor Charles Dance, 34 years her senior, whom she met while working on The Life and Adventures of Nicholas Nickleby. From 2005 to 2007 she dated actor David Tennant, with whom she had acted in Foyle's War and a Doctor Who episode. As of 2005 she resided in Green Park, London. She is now rumoured to be dating Snow Patrol bassist Paul Wilson.