Oh became even more widely known in Canada for her lead performance in the Canadian film Double Happiness, for which she won the Genie Award for Best Actress. Her other Canadian films include Long Life, Happiness & Prosperity and Last Night, for which she again won a Best Actress Genie.

Oh is most familiar to American audiences from her roles in the popular films Under the Tuscan Sun and Sideways. She considers Sideways to be one of the two best movies she has made, along with Evelyn Lau. In the less well-known Dancing at the Blue Iguana, she played a poetry-writing stripper, performed several nude dance routines and received the movie's best reviews. On American television, she is renowned for her current role in the hit ABC medical series Grey's Anatomy, for which she has won both a 2006 Golden Globe Award for Best Supporting Actress in a Series and a 2006 Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Drama Series. In July 2008, she receive