Rachel McAdams had the titular role in the film The Hot Chick alongside Rob Schneider, but her career really took off when she starred as Regina George, the "queen-bee" in 2004's Mean Girls. McAdams was told to partly model the character of Regina George after Alec Baldwin's performance in Glengarry Glen Ross (1992). She was much older than the character she played. McAdams had previously appeared in the Canadian television series Slings and Arrows, alongside Paul Gross. She played a main role in the first season, but due to her rising stardom was written out of the second season, appearing in only the first episode. She followed Mean Girls with the film adaptation of Nicholas Sparks' novel The Notebook, alongside Ryan Gosling, with whom she would later begin an off-screen romance. They broke up in 2007. Rumor says they are back again.

In 2005, she played Owen Wilson's love interest in Wedding Crashers and then starred in the suspense thriller Red Eye as Lisa Reisert. She play