From 1993 to 1998, Latifah had a starring role on Living Single, a FOX sitcom; she also wrote and performed its theme music. She began her film career in supporting roles in the 1991 films House Party 2, Juice, and Jungle Fever. She had her own talk show, The Queen Latifah Show, from 1999 to 2001.

Latifah first attracted notice for her role portraying a lesbian in the 1996 box-office hit, Set It Off and subsequently had a supporting role in the Holly Hunter film Living Out Loud (1998). She played the role of Thelma in the 1999 movie adaptation of Jeffrey Deavers' The Bone Collector, alongside Denzel Washington and Angelina Jolie. Although she had already received some critical acclaim, she gained mainstream success after being cast as Matron "Mama" Morton in the Oscar-winning musical Chicago, the recipient of the Best Picture Oscar. Latifah received an Academy Award nomination for Best Actress in a Supporting Role for her role, but lost to co-star Catherine Zeta-Jones. Latifah