Arquette was born in Chicago, Illinois and was raised in Virginia and California, the daughter of Mardi Olivia (née Nowak), an actress, poet, theater operator, activist, acting teacher and therapist, and Lewis Arquette, an actor. Arquette's paternal grandfather was comedian Cliff Arquette. Arquette's mother was Jewish, the daughter of a Holocaust refugee from Poland, and her father was a convert Read more...

At the age of eighteen Arquette got her start in show business in 1986's Pretty Smart. A year later, she gained attention for her starring role in A Nightmare on Elm Street 3: Dream Warriors, playing Kristen Parker. In 1993, she starred in Tony Scott's True Romance. Soon after, her career took off, and she has since appeared in such critically acclaimed movies as Ed Wood, Beyond Rangoon, Ethan Frome, Read more...

In April 1995, Arquette married Nicolas Cage (whom she would later co-star with in Bringing Out the Dead in 1999). They separated after nine months, but acted as a couple in public until Cage filed for divorce in February 2000. The divorce petition was withdrawn, but Arquette filed again in November 2000.

She and actor Thomas Jane became engaged in 2002 and married on June 25, 2006 at the Read more...