Sanderson joined Coronation Street in 1999 and left in Autumn 2005, when her character left Weatherfield to become a stylist for Status Quo. Prior to this, she had appeared in children's drama Children's Ward and in 2004, the hit fitness DVD Coronation Street - Funk fit.

Since leaving Coronation Street she has appeared in episodes of the BBC television series' Holby City and New Street Law alongside fellow Coronation Street alumni Chris Gascoyne and Chris Bisson. British newspaper The Daily Express stated that she was in the running[citation needed] to replace Billie Piper as the Doctor's companion in Doctor Who, however Freema Agyeman was chosen for the role. In 2006, Sanderson appeared in a touring production of The Vagina Monologues with Jerry Hall amongst others and an episode of Kay Mellor's Strictly Confidential.

A naturally gifted vocalist, Sanderson loves to show this side of herself off; jumping up to sing at every opportunity, she is a self-confessed karaoke