On December 14, 2006, car owner Larry Cahill announced that he had signed Duno to drive for his team in the Indy Racing League IndyCar series for 2007. However, the team did not ultimately enter the series, and consequently, on March 23, 2007, Duno and her Grand Am Series team, SAMAX Motorsport, sponsored by Citgo (a Venezuelan state-owned oil company), announced that they acquired the equipment to run a 10 race IndyCar series schedule in 2007, including the Indianapolis 500. It was also announced that Duno will no longer run a full schedule in the Grand Am series.

On April 26, 2007, Duno successfully passed her IRL rookie test at Kansas Speedway. When Duno made the field for the Kansas Lottery Indy 300 (also held at Kansas Speedway) on April 29, 2007, it marked the first time in North American open wheel history that three women (Duno, Danica Patrick and Sarah Fisher) ran in the same race. Duno stayed out of trouble after qualifying last in the 21-car field and finished 14th.