Mullally was born in Los Angeles, California, the daughter of Martha (née Palmer), a model, and Carter Mullally, Jr., an actor who was a contract player with Paramount Pictures during the 1950s. She is of Irish descent. Mullally moved to her father's native Oklahoma City, Oklahoma, at the age of seven. She studied ballet from the age of six and performed in a ballet company during high school. Read more...

Mullally moved to Los Angeles in 1981, after just two weeks as a client with the William Morris Agency, she began appearing in bit parts in films and television, such as Murder She Wrote with Angela Lansbury. She made her series debut in The Ellen Burstyn Show and guest starred in popular sitcoms such as Seinfeld, Frasier, Wings, Ned and Stacey (with future Will & Grace castmate Debra Messing, Read more...

Mullally commented in an interview in The Advocate magazine, "I consider myself bisexual, and my philosophy is, everyone innately is."

Mullally dated actor William H. Macy while in college. Her first marriage, in the mid-1990s, was to talent agent Michael Katcher. In 2003, Mullally married actor Nick Offerman (who guest-starred on Will & Grace during its fourth season). She currently lives Read more...