In the late 1980s, Le Blanc began appearing in a number of television ads, including well-known spots for Heinz, Levi's and Coca-Cola. Matt has said that with one ketchup commercial he was able to buy a house, a car, a motorcycle, and a wardrobe full of clothes.

In 1988, he landed his first regular TV role on the drama TV 101 which ran for one season. In the late 1980s, he also starred in Bob Seger's "Night Moves" music video. In 1990 he starred in Jon Bon Jovi's music video "Miracle", from the Young Guns II sound track. In 1991 he starred in the music video for Alanis Morissette's single "Walk Away", in which he played her boyfriend. Later in 1991, he went on to star in a spin-off of Married With Children entitled Top of the Heap. The short lived series only lasted 7 episodes in April and May of 1991. He also played his Top of the Heap character Vinnie Verducci in a number of Married With Children episodes. Le Blanc also appeared in one episode of Red Shoe Diaries in 1991.