Sirtis started her career as a member of the repertory company at the Connaught Theatre, Worthing, West Sussex in 1976. Directed by Nic Young, she appeared in Joe Orton's What the Butler Saw and as Ophelia in Hamlet.

Before her role in Star Trek, Sirtis had provocative, sexually-themed roles in several movies. In the Faye Dunaway film The Wicked Lady, she engaged in a topless whip fight with Read more...

Gene Roddenberry was inspired to ask the exotic-looking Sirtis to audition for a role after seeing the film Aliens with Bob Justman, which featured the prominent Latina character Vasquez, played by Jenette Goldstein. Sirtis and Denise Crosby initially tried out for the other's eventual role on The Next Generation. Sirtis's character was going to be named Lt. Macha Hernandez, the Security Chief. Read more...

After the end of Star Trek: The Next Generation in 1994, Sirtis continued to work regularly. She gained experience as a voice actress from the 1994 Disney animated television series Gargoyles, where she provided her voice for the antagonistic character Demona.

She appeared in other genre television shows such as Stargate SG-1 playing the Russian Dr. Svetlana Markov and as Sister Margaret in Read more...