Moore dated actor Wilmer Valderrama for eighteen months between 2000 and 2002; in 2006, Valderrama appeared on The Howard Stern Show and detailed that he and Moore were each other's "first loves", although he did not claim that their relationship was sexual, as was alleged by several media sources who had misquoted his exact comments. Moore later referred to Valderrama as a "good guy" and a "gentleman", although she has stated that his comments about their relationship were "utterly tacky". Moore began dating tennis star Andy Roddick in 2002; Roddick ended the relationship in March 2004. Moore also dated Philippines-born singer/actor Billy Crawford for a "few months" when she was younger.

In 2004, Moore began dating Scrubs actor Zach Braff, whom she met around November 2004. Referring to Braff, Moore said that she likes "good Jewish boy(s)... with a sense of humor". In 2006, the two were incorrectly reported to be engaged; they ended their relationship the same year. In early