Gibbons has been married three times. Her first was to John Hicks from 1980-82. From 1989- 91 she was married to British actor Christopher Quinten, with whom she has daughter Jordan Alexandra (Lexi) Gibbons. Her third marriage began in 1991 to Stephen Meadows. They have sons Troy and Nathan Daniel. Meadows filed for divorce in February 2005, after 14 years of marriage to Gibbons.

Gibbons is active in her non-profit organization, "Leeza's Place," an organization that educates and empowers caregivers of loved ones affected by memory disorders. Gibbons also has a star on The Hollywood Walk of Fame for television.