Loken was born in Ghent, New York, the daughter of Rande (née Porath), a model, and Merlin "Chris" Loken, a writer and apple farmer. Both her paternal and maternal grandparents were born in Norway and immigrated to Wisconsin's Norwegian American community. She grew up on her parents' fruit farm in Upstate New York. She has a sister named Tanya.

Loken started her acting career in 1994, playing "Danielle 'Dani' Andropoulos #3" on an episode of As The World Turns, and she appeared in several television shows and films, including regular appearances on the television shows Philly, Unhappily Ever After, Mortal Kombat: Conquest, and Boy Meets World. She is probably best known for her performance as the cybernetic warrior T-X (Terminatrix) in Read more...

Loken stated in an interview with Curve magazine, "I have dated and have had sex with men and women and have to say that the relationships I have had with certain women have been much more fulfilling, sexually and emotionally, than of those with certain men... I connect with an aura, with energy. And if the person with whom I connect happens to be a female, that's just the way it is. That's what Read more...