After leaving Juilliard, he had a three-year internship with the Old Globe Theater in San Diego in the late 1970s before a stint in 1980 at the Guthrie Theater in Minneapolis, Minnesota. He made his Broadway debut in 1981 as Lennox in Macbeth, taking the lead role when Philip Anglim withdrew after receiving negative reviews. In 1983 he performed on the demo of the Stephen Sondheim-James Lapine production Read more...

His television career began in the early 1980s when he portrayed Stephen Smith in the NBC mini-series Kennedy. Grammer came to broader public attention as Dr. Frasier Crane in the TV sitcom Cheers. Grammer's former Juilliard classmate and Broadway co-star Patinkin suggested Grammer to the New York casting director, and he got what was supposed to be a six-episode job, but ended up as a regular cast Read more...

Grammer's smooth, deep voice and Mid-Atlantic accent makes him popular for voiceover work. He has provided the voice of Sideshow Bob on The Simpsons, winning an Emmy for his work in the episode "The Italian Bob". He has appeared in ten episodes since the show's inception in 1989. He also supplied the voices for "Stinky Pete the Prospector" in Toy Story 2, Vladimir in the Fox animated movie Anastasia, Read more...