Chambers was born in Springfield, Ohio, to Pam and John Chambers of Irish and German descent. He has a twin brother named Jason, one older brother Chip (John); and two older sisters, Mia and Susan. He and his twin brother visited hospitals often as children due to frequent bouts with pneumonia. He attended Springfield Christian elementary school. He has five children with his wife, Keisha: Isabella (1997), the twins Maya and Kaila (1999), Eva (2001) and Jackson (2002). Keisha is a former model agency booker whom he married in 1993. His wife and children have recently moved to Los Angeles from their home in a suburb just outside of New York City.