Emmanuelle Vaugier can currently be seen in a recurring guest star role on CBS' CSI: NY as Detective Jennifer "Jen" Angell.

Her most well-known roles have been on Two and a Half Men, Smallville, and Painkiller Jane. In 2005 - 2006, she guest starred in six episodes of CBS' hit sitcom Two and a Half Men as Mia, a ballet teacher who Charlie Harper fell in love with and almost married. In 2005, she also played the title character in the pilot episode of the television adaptation of the comic Painkiller Jane for the Sci Fi Channel. However, she first became noticed by the sci-fi community when she portrayed Dr. Helen Bryce, the love interest of Lex Luthor, on the WB’s hit drama Smallville in 2002 - 2003.

In 2004, she played Lindsey Kellogg on the short-lived Fox Television series North Shore. She has also had guest star spots on Veronica Mars, Supernatural, The Outer Limits, Higher Ground, Andromeda, and Charmed. Emmanuelle also appeared in the Emmy Award nominated miniser