Meyer's film debut was in the TV film Strapped in 1993, although her role in the cyberpunk thriller Johnny Mnemonic was perhaps her breakthrough performance. Before that, however, she also had a role in the TV series Beverly Hills 90210 as Lucinda Nicholson. In addition to Johnny Mnemonic, she has had other roles in science fiction productions, such as Starship Troopers, Birds of Prey and Star Trek Nemesis. Three of her most recent films were the 2004 horror/thriller hit Saw, followed by its sequels Saw II, Saw III and Saw IV. She made several guest appearances on Friends and Miss Match. She also played one of the leads on the now canceled Point Pleasant. In March 2006 Meyer was in the series premiere episode of Thief as Wanda, the wife of Andre Braugher's character Nick, although her character did not reappear.