Schwimmer is best known for his role as palaeontologist Dr. Ross Geller in the television sitcom Friends. The program was hugely successful and Schwimmer, along with his co-stars, gained widespread and worldwide recognition among television viewers. He earned an Emmy Award nomination in the “Outstanding Supporting Actor in a Comedy Series” category for the role in 1995. This made him the first cast member of Friends to receive such a nomination.

Aside from acting, he also directed 10 episodes of the series.' During the show’s 10-year run, Schwimmer appeared in numerous movies but perhaps gained most recognition outside of Friends playing Captain Herbert Sobel in the dramatic mini-series Band of Brothers. He was the first Friends character to host Saturday Night Live in 1995, with all the other main cast members to follow in his footsteps over the rest of the seasons in the '90s, apart from Matt LeBlanc who never hosted.

Schwimmer played himself on the HBO series