At the age of 16, Theron traveled to Milan, Italy, on a one-year modeling contract, after winning a local competition. She went to New York with Pauline's Model Management. She decided to remain after her contract ended, attending the Joffrey Ballet School, where she trained as a ballet dancer. A knee injury closed this career path when Theron was 19.

Unable to dance, Theron flew to Los Angeles on a one-way ticket her mother bought her. During her early months there, she went to a bank to cash a check her mother had sent her to help with the rent. When the teller refused to cash it, Theron immediately started into a shouting match with her. Afterwards, a talent agent in line behind her handed her his business card and subsequently introduced her to some casting agents and also an acting school. She later fired him as her manager after he kept sending her scripts for films similar to Showgirls and Species, which would have traded solely on her appearance.

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