Fisher was married to musician Paul Simon and was in a relationship with him for several years afterwards. During their marriage, she appeared in Simon's music video for the track "Rene And Georgette Magritte With Their Dog After The War". She is referenced in many of Simon's songs, including "Hearts and Bones", "Graceland", "She Moves On", and "Allergies".

Subsequently, she had a relationship with Creative Artists Agency principal and agent Bryan Lourd. They had one child together, Billie Catherine Lourd (born July 17, 1992). The couple's relationship ended when Lourd left her for a man. She was linked for a time to Senator Christopher Dodd and was briefly engaged to Dan Aykroyd. She also dated broadcast reporter Bob Tur in 2004-2005.

In an interview on public radio in 2005, Fisher joked that she was afraid if she ever became senile she might begin to slip back into her Princess Leia character. Fisher has publicly discussed her problems with drugs, her battles with bipo