The son of Italian actor Antonio Sabàto Sr., and his Czech-born wife Yvonne Kabouchy, the family moved to the United States when he was 12. He attended St. Bernard High School (Los Angeles, California) before transferring to Beverly Hills High School in Beverly Hills, California. Sabàto became a naturalized citizen of the United States in November of 1996.

Sabàto first gained attention as a Calvin Klein underwear model, and appeared in Janet Jackson's Love Will Never Do (Without You) music video along with actor Djimon Hounsou, who is also a former CK underwear model, in 1990. Moving into acting, from 1992 through 1995 he appeared on the soap opera General Hospital, the SF series Earth 2, and on the prime-time soap opera Melrose Place.

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Sabàto was married to Alicia Tully Jensen from 1992 to 1993. He also dated Nicolette Scorsese in the 1980s. He has two children, a son, Jack Antonio (born August 6, 1994) with actress Virginia Madsen, and a daughter, Mina Bree (born August 29, 2002) with his then girlfriend Kristin Rossetti he is currently single.